However, he fell into habits which conflicted with his calling—drinking like his father and probably also womanizing.This led him after several years of conflict to leave the church, ceasing his full-time commitment, although he continued to preach sermons from time to time.After a couple of years, feeling used and disillusioned, House recalled, "I left her hanging on the gatepost, with her father tellin' me to come back so we could plow some more." Around the same time, probably 1922, House's mother died.In later years, he was still angry about his marriage and said of Carrie, "She wasn't nothin' but one of them New Orleans whores".Issued at the start of the Great Depression, the records did not sell and did not lead to national recognition.Locally, House remained popular, and in the 1930s, together with Patton's associate Willie Brown, he was the leading musician of Coahoma County.In 1964, a group of young record collectors discovered House, whom they knew of from his records issued by Paramount and by the Library of Congress.With their encouragement, he relearned his repertoire and established a career as an entertainer, performing for young, mostly white audiences in coffeehouses, at folk festivals and on concert tours during the American folk music revival, billed as a "folk blues" singer.
His father, Eddie House, Sr., was a musician, playing the tuba in a band with his brothers and sometimes playing the guitar.
He recorded several albums, and some informally taped concerts have also been issued as albums. In addition to his early influence on Robert Johnson and Muddy Waters, he was an inspiration to John Hammond, Alan Wilson (of Canned Heat), Bonnie Raitt, the White Stripes, Dallas Green and John Mooney.